Ipamorelin is a selective pentapeptide agonist at the ghrelin GHS-R1a receptor. It is used in pituitary somatotroph culture and studied for its receptor selectivity, with minimal cross-activity at ACTH and prolactin endpoints. NuVion stocks it in Australia as a 10mg lyophilised vial.
- Selective pentapeptide agonist at the ghrelin GHS-R1a receptor
- Used in pituitary somatotroph culture models
- Applied in receptor selectivity and second messenger assays
- Supplied lyophilised, purity by RP-HPLC and identity by mass spectrometry
Ipamorelin structure and research use
Ipamorelin has the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2. It belongs to the growth hormone releasing peptide family, synthetic agonists of the ghrelin receptor GHS-R1a, alongside GHRP-2 and GHRP-6. What sets it apart in the literature is selectivity: in somatotroph work it shows minimal cross-activity at ACTH and prolactin endpoints.
Ipamorelin research applications
- Competition binding at recombinant GHS-R1a in membrane preparations, run against labelled ghrelin or small-molecule tracers
- Calcium mobilisation in HEK293 or CHO lines stably expressing GHS-R1a, read with fluorescent calcium indicators
- IP-One accumulation assays measuring Gq pathway output, paired with transcriptional reporter readouts of that branch
- Beta-arrestin recruitment and receptor internalisation measured by BRET, enzyme complementation or imaging formats
Ipamorelin key facts
| Type | Synthetic pentapeptide, GHS-R1a agonist |
|---|---|
| Amino acid count | 5 |
| Also known as | NNC 26-0161, ipamorelin acetate (salt form) |
| Vial size | 10mg, lyophilised |
| Purity | 99.71% by RP-HPLC, Janoshik Analytical |
| Analysed | 9 July 2026 |
Research profile: Ipamorelin: structure, mechanism and research use
Independent test: a sample of this product was analysed by Janoshik Analytical on 9 July 2026, purity 99.71% by RP-HPLC, test number 195040. The full report opens from the lab band on this page.







