Neuroscience

The neuroscience category covers peptides used in neuronal cell models to study neurotrophin expression, BDNF and TrkB signalling, and ion channel pharmacology. Semax is a heptapeptide analogue of the ACTH 4-10 fragment used in BDNF and TrkB expression assays in cultured neurons, and Selank is a heptapeptide analogue of tuftsin used in gene expression and GABA-A receptor binding studies in neuronal cell models. PE-22-28 is a shortened spadin analogue that inhibits the TREK-1 potassium channel and is used in patch clamp electrophysiology and channel binding work. P21 is a small peptide derived from ciliary neurotrophic factor, characterised in neuronal differentiation and neurogenesis-related signalling assays. Pinealon is the tripeptide Glu-Asp-Arg used in gene expression and redox signalling studies in neuronal culture, Cerebrolysin is a peptide mixture with neurotrophic-factor-like activity in culture, and DSIP is a nonapeptide used in receptor and neuroendocrine cell assays.
Peptides acting at melanocortin and oxytocin receptors sit in the reproductive signalling category. Compounds in this category are independently tested by Janoshik Analytical for RP-HPLC purity and mass spectrometry identity, with the Certificate of Analysis for tested batches published on the product page. Supplied as laboratory chemicals for in vitro research use only, dispatched from within Australia.

Structure, mechanism, handling and analysis notes for these compounds are in the NuVion peptide research library: Selank, Semax, Cerebrolysin, DSIP, P21, PE-22-28 and Pinealon.