PE-22-28 is a synthetic seven amino acid analogue of spadin and a selective TREK-1 potassium channel blocker. It is used in neuronal culture and neurogenesis research models, with reported potency greater than the parent spadin sequence.
- Synthetic 7-amino acid analogue of spadin
- Sequence Gly-Val-Ser-Trp-Gly-Leu-Arg
- Selective TREK-1 potassium channel blocker
- IC50 of 0.12 nM (more potent than parent spadin)
- Studied in TREK-1 channel and neurogenesis research models
Research profile: PE-22-28: structure, mechanism and research use





