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NuVion Semax research peptide vial

Semax

Original price was: A$69.00.Current price is: A$59.00.

Semax, a modified ACTH (4-10) fragment studied in neuronal culture research.

Research use only. Not for human or veterinary use.

In stock

All prices are in AUD. Ships from Australia with tracked express shipping, $15 flat, 1 to 2 business days, free on orders over $200. Research use only, not for human or veterinary use.

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  • Dispatched from Australia
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Research use only

Not for human or veterinary use.

Laboratory chemical

Supplied for in vitro research. We publish specifications and handling guidance only, with no protocols and no advice on use.

Not on the ARTG

Absent from the Australian Register of Therapeutic Goods and never evaluated by the TGA for safety, quality or efficacy. Absence from the register is not an approval and does not authorise any other use.

Who can order

You must be 18 or over and purchasing solely for lawful research.

What is Semax?

Semax is a modified ACTH (4-10) fragment with improved resistance to enzymatic degradation. It is used in neuronal culture and brain slice preparations to study BDNF expression and synaptic plasticity, and NuVion stocks it in Australia as a 10mg lyophilised vial.

  • Modified ACTH (4-10) fragment with improved resistance to degradation
  • Used in neuronal culture and brain slice preparations
  • Applied in BDNF and neurotrophic factor expression assays
  • Supplied lyophilised, purity by RP-HPLC and identity by mass spectrometry

Semax structure and research use

Semax has the sequence Met-Glu-His-Phe-Pro-Gly-Pro. The first four residues come from adrenocorticotropic hormone, positions 4 to 7, and the Pro-Gly-Pro tail was added to slow enzymatic breakdown. In the laboratory it is used in neuronal culture and brain slice preparations for work on BDNF expression and synaptic plasticity.

Semax research applications

  • BDNF and NTRK2 transcript measurement by qPCR in primary cortical or hippocampal neuron culture and in glial culture
  • TrkB autophosphorylation with ERK1/2, Akt and CREB phosphorylation by Western blot, run with TrkB kinase inhibitor controls
  • Neurite outgrowth and differentiation assays in PC12 and SH-SY5Y cells, scored by image analysis
  • Melanocortin receptor binding and cAMP assays, with Semax as the structurally related inactive comparator to alpha-MSH

Semax key facts

Type Synthetic peptide, ACTH(4-7) analogue with a C-terminal Pro-Gly-Pro extension
Amino acid count 7
Sequence H-Met-Glu-His-Phe-Pro-Gly-Pro-OH (MEHFPGP)
Also known as ACTH(4-7)PGP, Met-Glu-His-Phe-Pro-Gly-Pro
Vial size 10mg, lyophilised
Purity 99.57% by RP-HPLC, Janoshik Analytical
Analysed 5 February 2026

See how Semax compares in Semax vs Selank. NuVion also sells Semax in the Neuropeptide Signalling Set, with each compound in its own vial.

Research profile: Semax: structure, mechanism and research use

Independent test: a sample of this product was analysed by Janoshik Analytical on 5 February 2026, purity 99.57% by RP-HPLC. The certificate is shown in the lab band on this page.

Why buy Semax from NuVion

Testing status on every page

Published results show the measured purity, the date and the certificate.

Australian stock, domestic post

Held in Australia and sent tracked in plain outer packaging.

Specifications

Chemical structure of Semax Semax certificate of analysis from Janoshik Analytical, 99.57% purity
Sequence Length 7
CAS Number 80714-61-0
Molecular Weight 813.9
Molecular Formula C37H51N9O10S

Storing and handling Semax

Before reconstitution
Keep the sealed vial cool, dry and out of direct light. General practice for lyophilised peptides.
After reconstitution
Reconstitute with bacteriostatic or sterile water, store at 2 to 8°C and avoid repeated freeze-thaw cycles. No stability-tested shelf life is published for this product.

Reconstitution and storage Volumes, concentrations and storage at a glance.

Semax questions

Where can I buy Semax in Australia?
NuVion stocks Semax in Australia as a 10mg vial of lyophilised powder, posted from Australian stock on a tracked express service. A sample was analysed by Janoshik Analytical on 5 February 2026, with purity of 99.57% by RP-HPLC. It also comes in the Neuropeptide Signalling Set and the Semax & Selank Pair. Bacteriostatic water is sold separately. Semax is supplied as a research material only and is not on the Australian Register of Therapeutic Goods.
What is Semax used for in research?
It is used in neuronal and glial cell culture to study BDNF and TrkB expression and the ERK, Akt and CREB signalling downstream of TrkB. It also appears in transcriptomic profiling of neuronal cultures, in neurite outgrowth assays, and as a melanocortin-derived comparator peptide in receptor binding and cAMP assays.
How does Semax work at the cell level?
The mechanism described most consistently in cell models runs through the neurotrophin system. Exposure of neuronal and glial cultures to Semax raises transcript levels for brain-derived neurotrophic factor (BDNF) and for its receptor TrkB, measured by qPCR, with matching changes in protein by Western blot or ELISA on culture supernatant. The Semax research profile covers the mechanism in full.
Which part of ACTH does Semax keep?
Semax keeps residues 4 to 7 of adrenocorticotropic hormone, Met-Glu-His-Phe, and adds a Pro-Gly-Pro extension. It carries the His-Phe half of the melanocortin binding motif without the Arg-Trp half, so it has no useful affinity for MC1R to MC5R in binding assays.
Why does Semax bind copper?
The histidine at position 3 sits behind a free alpha-amino group, an arrangement known as an ATCUN motif. It chelates Cu(II) in a square-planar complex through the N-terminal amine, two backbone amide nitrogens and the imidazole, so trace copper in a buffer can change what is measured.
How does Semax oxidation show up on RP-HPLC?
The methionine at position 1 oxidises readily to the sulfoxide, which adds 16 Da. It appears as a shoulder or an earlier-eluting peak on a reversed-phase gradient. Quantification is normally done at 214 nm, since the single phenylalanine gives only weak absorbance near 258 nm.
What is the difference between Semax and Selank?
Semax is built on a fragment of ACTH. Selank is an analogue of the immunoglobulin fragment tuftsin. Both carry the same Pro-Gly-Pro tail. NuVion stocks each on its own and both together as the Semax and Selank Pair.

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