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NuVion Kisspeptin research peptide vial

Kisspeptin

A$89.00

Kisspeptin, a neuropeptide studied in reproductive hormone signalling.

Research use only. Not for human or veterinary use.

In stock

All prices are in AUD. Ships from Australia with tracked express shipping, $15 flat, 1 to 2 business days, free on orders over $200. Research use only, not for human or veterinary use.

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Research use only

Not for human or veterinary use.

Laboratory chemical

Supplied for in vitro research. We publish specifications and handling guidance only, with no protocols and no advice on use.

Not on the ARTG

Absent from the Australian Register of Therapeutic Goods and never evaluated by the TGA for safety, quality or efficacy. Absence from the register is not an approval and does not authorise any other use.

Who can order

You must be 18 or over and purchasing solely for lawful research.

What is Kisspeptin?

Kisspeptin is the neuropeptide product of the KISS1 gene and the ligand at the KISS1R receptor. It is used in hypothalamic neuron and GnRH cell models to study the reproductive axis and gonadotropin signalling, and NuVion stocks it in Australia as a 10mg lyophilised vial.

  • Neuropeptide product of the KISS1 gene, ligand at the KISS1R receptor
  • Used in hypothalamic neuron and GnRH cell models
  • Applied in receptor binding and GnRH release assays
  • Supplied lyophilised, purity by RP-HPLC and identity by mass spectrometry

Kisspeptin structure and research use

The KISS1 gene encodes a precursor that is cut into several kisspeptins of different lengths. All of them share the same ten amino acids at the C-terminus, which is the part that activates the receptor. That receptor, KISS1R, is a G protein-coupled receptor also known as GPR54. In the laboratory kisspeptin is used in hypothalamic neuron and GnRH cell models for work on receptor binding and gonadotropin signalling.

Kisspeptin research applications

  • Calcium mobilisation by fluorescent dye or aequorin in CHO or HEK293 cells stably expressing KISS1R
  • Competition against iodinated tracer in radioligand binding, used to define the pharmacology of KISS1R antagonists
  • ERK1/2 and p38 phosphorylation readouts used to map KISS1R signalling and receptor desensitisation
  • Electrophysiology and GnRH secretion measurements in GnRH-expressing neuronal cell lines and KISS1R-transfected cells

Kisspeptin key facts

Type Synthetic RFamide peptide, KISS1R agonist
Amino acid count 10, C-terminally amidated
Sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Also known as Kisspeptin-10, KP-10, metastin (45-54), KiSS-1 (112-121)
Vial size 10mg, lyophilised
Purity 99.85% by RP-HPLC, Janoshik Analytical
Analysed 27 March 2026

Research profile: Kisspeptin: structure, mechanism and research use

Independent test: a sample of this product was analysed by Janoshik Analytical on 27 March 2026, purity 99.85% by RP-HPLC. The certificate is shown in the lab band on this page.

Why buy Kisspeptin from NuVion

Testing status on every page

Published results show the measured purity, the date and the certificate.

Australian stock, domestic post

Held in Australia and sent tracked in plain outer packaging.

Specifications

Chemical structure of Kisspeptin Kisspeptin certificate of analysis from Janoshik Analytical, 99.85% purity
CAS Number 374675-21-5
Molecular Weight 1302.4
Molecular Formula C63H83N17O14

Storing and handling Kisspeptin

Before reconstitution
Keep the sealed vial cool, dry and out of direct light. General practice for lyophilised peptides.
After reconstitution
Reconstitute with bacteriostatic or sterile water, store at 2 to 8°C and avoid repeated freeze-thaw cycles. No stability-tested shelf life is published for this product.

Reconstitution and storage Volumes, concentrations and storage at a glance.

Kisspeptin questions

Where can I buy kisspeptin in Australia?
NuVion stocks kisspeptin in Australia as a 10mg vial of lyophilised powder, posted from Australian stock on a tracked express service. A sample was analysed by Janoshik Analytical on 27 March 2026, with purity of 99.85% by RP-HPLC. Bacteriostatic water is sold separately. kisspeptin is supplied as a research material only and is not on the Australian Register of Therapeutic Goods.
What is kisspeptin used for in research?
Kisspeptin-10 is the standard agonist for characterising KISS1R. It is used to calibrate calcium and inositol phosphate assays, as the competing ligand in binding studies, and as the stimulus in ERK phosphorylation, arrestin recruitment and GnRH secretion experiments in cell lines.
How does Kisspeptin work at the cell level?
KISS1R is a class A G protein-coupled receptor that couples to Gq/11. Agonist binding activates phospholipase C beta, which hydrolyses phosphatidylinositol 4,5-bisphosphate to inositol trisphosphate and diacylglycerol. Inositol trisphosphate releases calcium from the endoplasmic reticulum, and diacylglycerol activates protein kinase C. The Kisspeptin research profile covers the mechanism in full.
Why is Kisspeptin classed as an RFamide peptide?
Kisspeptin ends in Arg-Phe-NH2, the C-terminal motif of the RFamide family. Other members include neuropeptide FF, prolactin-releasing peptide and the RFRP peptides, which is why cross-reactivity at NPFF receptors is checked when it is used at high concentration.
What is the shortest part of Kisspeptin that still activates KISS1R?
The C-terminal pentapeptide Phe-Gly-Leu-Arg-Phe-NH2 still binds and activates KISS1R on its own, though with lower affinity. The ten-residue Kisspeptin is the shortest fragment that retains full agonist activity, and the C-terminal amide is required for receptor recognition.
Which residues in Kisspeptin are most prone to chemical change?
The asparagine residues at positions 2 and 4 are susceptible to deamidation, and the tryptophan at position 3 is susceptible to oxidation. Deamidation products separate from the parent peak on a standard C18 gradient, so RP-HPLC shows them.
What receptor does kisspeptin act on?
KISS1R, a G protein-coupled receptor that is also called GPR54. Kisspeptin is its natural ligand.

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