PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide analogue of alpha-MSH, active at the MC1R, MC3R and MC4R melanocortin receptors. It is used in hypothalamic neuron culture to study receptor binding and second messenger response, and NuVion stocks it in Australia as a 10mg lyophilised vial.
- Synthetic cyclic heptapeptide analogue of alpha-MSH
- Agonist at the MC1R, MC3R and MC4R melanocortin receptors
- Used in hypothalamic neuron culture models
- Supplied lyophilised, purity by RP-HPLC and identity by mass spectrometry
PT-141 structure and research use
PT-141 has the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH. It shares its seven amino acid ring with Melanotan 2 and differs at the C-terminus, which ends in a free acid where Melanotan 2 ends in an amide. In the laboratory it is used in hypothalamic neuron models for work on melanocortin receptor binding and second messenger response.
PT-141 research applications
- HTRF or ELISA cAMP accumulation for concentration-response curves on recombinant melanocortin receptor cell lines
- Electrophysiology of Kir7.1 potassium channel coupling in cells expressing MC4R
- Rightward shift of cAMP curves by AgRP, ASIP or SHU9119 when characterising antagonists and allosteric modulators
- Model cyclic lactam peptide for studies of how cyclisation and D-amino acids affect protease resistance
PT-141 key facts
| Type | Synthetic cyclic peptide, melanocortin receptor agonist |
|---|---|
| Amino acid count | 7 |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Also known as | Bremelanotide, PT141 |
| Vial size | 10mg, lyophilised |
| Purity | 99.70% by RP-HPLC, Janoshik Analytical |
| Analysed | 27 March 2026 |
Research profile: PT-141: structure, mechanism and research use
Independent test: a sample of this product was analysed by Janoshik Analytical on 27 March 2026, purity 99.70% by RP-HPLC. The certificate is shown in the lab band on this page.
