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NuVion MOTS-C research peptide vial
Janoshik certificate of analysis for MOTS-c

MOTS-C

Price range: A$69.00 through A$129.00

MOTS-C, a mitochondrial-derived peptide studied in AMPK and energy research.

Research use only. Not for human or veterinary use.

All prices are in AUD. Ships from Australia with tracked express shipping, $15 flat, 1 to 2 business days, free on orders over $200. Research use only, not for human or veterinary use.

  • Testing status on this page
  • Same-day dispatch before 2pm
  • Dispatched from Australia
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Research use only

Not for human or veterinary use.

Laboratory chemical

Supplied for in vitro research. We publish specifications and handling guidance only, with no protocols and no advice on use.

Not on the ARTG

Absent from the Australian Register of Therapeutic Goods and never evaluated by the TGA for safety, quality or efficacy. Absence from the register is not an approval and does not authorise any other use.

Who can order

You must be 18 or over and purchasing solely for lawful research.

What is MOTS-C?

MOTS-C, also written MOTS-c, is a sixteen amino acid mitochondrial-derived peptide encoded in mitochondrial DNA. It is used in myotube, hepatocyte and adipocyte culture to study AMPK phosphorylation, glucose uptake and metabolic homeostasis, and NuVion stocks it in Australia in 10mg and 20mg vials.

  • Sixteen amino acid peptide encoded in mitochondrial DNA
  • Used in myotube, hepatocyte and adipocyte culture models
  • Applied in AMPK phosphorylation and glucose uptake assays
  • Supplied lyophilised, purity by RP-HPLC and identity by mass spectrometry

MOTS-C structure and research use

MOTS-C is encoded by a short open reading frame inside the mitochondrial 12S rRNA gene, which makes it one of a small group of peptides that originate from mitochondrial DNA and not from the nucleus. In cell culture it is used to study AMPK activation, glucose uptake and mitochondrial signalling in myotube, hepatocyte and adipocyte models.

MOTS-C vial sizes and prices, 10mg and 20mg

NuVion stocks MOTS-C in 10mg and 20mg vials. Both hold the same lyophilised peptide, and the 20mg vial works out cheaper per milligram.

MOTS-C vial sizes and prices in AUD
Vial sizePricePrice per mgAvailability
MOTS-C 10mgA$69.00A$6.90/mgIn stock
MOTS-C 20mgA$129.00A$6.45/mgIn stock

MOTS-C research applications

  • Western blot for phospho-Thr172 AMPK and phospho-ACC in myoblasts, myotubes or HEK293 cells
  • Glucose uptake assays with 2-deoxyglucose or 2-NBDG in differentiated myotubes, alongside GLUT4 expression
  • LC-MS metabolomics following 5-methyltetrahydrofolate, S-adenosylmethionine and AICAR after peptide exposure in cultured cells
  • ARE-driven luciferase reporters and qPCR for the NRF2 target genes HMOX1 and NQO1

MOTS-C key facts

Type Synthetic peptide, mitochondrial-derived peptide
Amino acid count 16
Sequence MRWQEMGYIFYPRKLR (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg)
Also known as Mitochondrial ORF of the 12S rRNA type-c, MT-RNR1-derived peptide
Purity 99.28% by RP-HPLC, Janoshik Analytical
Analysed 24 September 2026

See how MOTS-C compares in MOTS-C vs SS-31. NuVion also sells MOTS-C in the Somatotropic Axis Set, Cellular Ageing Set (Extended), Metabolic Signalling Set (Extended), NNMT and Mitochondrial Pair and Incretin and Mitochondrial Pair, with each compound in its own vial.

Research profile: MOTS-c: structure, mechanism and research use

Independent test: a sample of this product was analysed by Janoshik Analytical on 24 September 2026, purity 99.28% by RP-HPLC, test number 234335. The full report opens from the lab band on this page.

Why buy MOTS-C from NuVion

Testing status on every page

Published results show the measured purity, the date and the certificate.

Australian stock, domestic post

Held in Australia and sent tracked in plain outer packaging.

Specifications

Chemical structure of MOTS-c MOTS-C certificate of analysis from Janoshik Analytical, test 234335, 99.28% purity
Sequence Length 16
CAS Number 1627580-64-6
Molecular Weight 2174.6
Molecular Formula C101H152N28O22S2

Storing and handling MOTS-C

Before reconstitution
Keep the sealed vial cool, dry and out of direct light. General practice for lyophilised peptides.
After reconstitution
Reconstitute with bacteriostatic or sterile water, store at 2 to 8°C and avoid repeated freeze-thaw cycles. No stability-tested shelf life is published for this product.

Reconstitution and storage Volumes, concentrations and storage at a glance.

MOTS-C reviews

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MOTS-C questions

Where can I buy MOTS-C in Australia?
NuVion stocks MOTS-C in Australia in 10mg and 20mg vials. Choose a size at the top of this page and check out, and the order is posted from Australian stock on a tracked express service. It is supplied as a research material only and is not on the Australian Register of Therapeutic Goods.
How much does MOTS-C cost in Australia?
MOTS-C is $69 AUD for the 10mg vial and $129 for the 20mg vial. The 20mg vial is the lower price per mg at $6.45.
What is MOTS-c used for in research?
It is used as a tool peptide for AMPK activation, one-carbon metabolism and nuclear stress response signalling in cultured cells. Typical readouts are AMPK phosphorylation, glucose uptake in myotubes, folate and purine intermediates by LC-MS, and NRF2 target gene expression.
How does MOTS-C work at the cell level?
MOTS-c has no identified cell-surface receptor. In cultured cells it acts intracellularly, and it is studied for its effect on one-carbon metabolism and on AMPK phosphorylation. The MOTS-C research profile covers the mechanism in full.
Where in the cell is MOTS-C translated?
MOTS-C is translated on cytoplasmic ribosomes. Its open reading frame sits within the mitochondrial MT-RNR1 gene, and the transcript is polyadenylated and read with the standard nuclear genetic code. Under the mitochondrial code a stop codon would interrupt the sequence.
Which residues in MOTS-C are most prone to oxidation?
The two methionines at positions 1 and 6 and the tryptophan at position 3 oxidise most readily. Mass spectrometry of stored solutions is checked for species 16 Da and 32 Da heavier, and oxidised forms elute earlier on a C18 column.
What is the Y8F variant of MOTS-C used for?
The Y8F variant is used as an inactive control in several cell-based assays. It replaces tyrosine 8 with phenylalanine. A second variant, K14Q, arises from a naturally occurring mitochondrial DNA change and swaps lysine 14 for glutamine.
What does MOTS-c stand for?
Mitochondrial open reading frame of the 12S rRNA type-c. The name describes where the peptide is encoded: a short open reading frame within the mitochondrial 12S rRNA gene.
What form does MOTS-C arrive in?
As a lyophilised (freeze-dried) powder in a sealed vial. Bacteriostatic water is sold separately.

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