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NuVion 5-Amino-1MQ research vial
Janoshik certificate of analysis for 5-Amino-1MQ

5-Amino-1MQ

Original price was: A$69.00.Current price is: A$59.00.

5-Amino-1MQ, an NNMT inhibitor studied in metabolism and NAD+ pathway research.

Research use only. Not for human or veterinary use.

In stock

All prices are in AUD. Ships from Australia with tracked express shipping, $15 flat, 1 to 2 business days, free on orders over $200. Research use only, not for human or veterinary use.

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Research use only

Not for human or veterinary use.

Laboratory chemical

Supplied for in vitro research. We publish specifications and handling guidance only, with no protocols and no advice on use.

Not on the ARTG

Absent from the Australian Register of Therapeutic Goods and never evaluated by the TGA for safety, quality or efficacy. Absence from the register is not an approval and does not authorise any other use.

Who can order

You must be 18 or over and purchasing solely for lawful research.

What is 5-Amino-1MQ?

5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase, studied for its role in cellular methylation and NAD+ metabolism. It is used as a research tool in adipocyte and hepatocyte models in vitro, and NuVion stocks it in Australia as a 10mg vial.

  • Small molecule inhibitor of nicotinamide N-methyltransferase (NNMT)
  • Used to probe NNMT activity in cell based assays
  • Applied in adipocyte and hepatocyte culture models
  • Purity confirmed by RP-HPLC, identity by mass spectrometry

5-Amino-1MQ structure and research use

5-Amino-1MQ is 5-amino-1-methylquinolinium, a small quinolinium compound with no amino acid chain. It inhibits nicotinamide N-methyltransferase, the enzyme that methylates nicotinamide, which makes it a tool for studying how NNMT activity connects to the NAD+ pathway and cellular methylation. In the laboratory it is used in adipocyte and hepatocyte models.

5-Amino-1MQ research applications

  • Recombinant NNMT enzyme assays quantifying 1-MNA or SAH formation by LC-MS for IC50 determination
  • Selectivity profiling against related SAM-dependent methyltransferases such as PNMT, HNMT, COMT and DNMT1
  • LC-MS/MS quantification of NAD+, NADH, nicotinamide, 1-MNA, SAM and SAH in NNMT-expressing cell lines
  • Gene expression by qPCR (Fasn, Srebf1, Pparg) in differentiating 3T3-L1 adipocyte cultures

5-Amino-1MQ key facts

Type Small molecule, quinolinium NNMT inhibitor (not a peptide)
Also known as 5-amino-1-methylquinolinium, 5-amino-1-methylquinoline, 5-Amino-1MQ, 5-A-1MQ
Vial size 10mg, lyophilised
Purity 99.41% by RP-HPLC, Janoshik Analytical
Analysed 11 November 2025

NuVion also sells 5-Amino-1MQ in the Metabolic Signalling Set, NAD Pathway Pair, Metabolic Signalling Set (Extended) and NNMT and Mitochondrial Pair, with each compound in its own vial.

Research profile: 5-Amino-1MQ: structure, mechanism and research use

Independent test: a sample of this product was analysed by Janoshik Analytical on 11 November 2025, purity 99.41% by RP-HPLC. The certificate is shown in the lab band on this page.

Why buy 5-Amino-1MQ from NuVion

Testing status on every page

Published results show the measured purity, the date and the certificate.

Australian stock, domestic post

Held in Australia and sent tracked in plain outer packaging.

Specifications

Janoshik certificate of analysis for 5-Amino-1MQ
Molecular Weight 159.21
Molecular Formula C10H11N2+ (cation; supplied as a salt)

Storing and handling 5-Amino-1MQ

Before reconstitution
Keep the sealed vial cool, dry and out of direct light. General practice for lyophilised peptides.
After reconstitution
Reconstitute with bacteriostatic or sterile water, store at 2 to 8°C and avoid repeated freeze-thaw cycles. No stability-tested shelf life is published for this product.

Reconstitution and storage Volumes, concentrations and storage at a glance.

5-Amino-1MQ reviews

5.0
★★★★★
1 review from verified buyers
I’ve placed a lot of orders with Nuvion now and will continue to do so. Great products, fast delivery, and always super helpful and quick to respond. Very happy customer here and wouldn’t hesitate to recommend them.
Justin✓ Verified buyer

5-Amino-1MQ questions

Where can I buy 5-Amino-1MQ in Australia?
NuVion stocks 5-Amino-1MQ in Australia as a 10mg vial of lyophilised powder, posted from Australian stock on a tracked express service. A sample was analysed by Janoshik Analytical on 11 November 2025, with purity of 99.41% by RP-HPLC. It also comes in the Metabolic Signalling Set, the NAD Pathway Pair, the Metabolic Signalling Set (Extended) and the NNMT & Mitochondrial Pair. Bacteriostatic water is sold separately. 5-Amino-1MQ is supplied as a research material only and is not on the Australian Register of Therapeutic Goods.
What is 5-Amino-1MQ used for in research?
It is used as a selective, cell-permeable NNMT inhibitor. Typical work includes methyltransferase enzyme assays, selectivity profiling against other SAM-dependent methyltransferases, and cell culture studies that read out NAD+, SAM and SAH pools or lipogenic gene expression in NNMT-expressing lines such as 3T3-L1 adipocytes.
How does 5-Amino-1MQ work at the cell level?
5-Amino-1MQ inhibits NNMT, the enzyme that transfers a methyl group from S-adenosylmethionine to nicotinamide, producing 1-methylnicotinamide and S-adenosylhomocysteine. The reaction sits at the junction of the methylation cycle and the NAD+ salvage pathway. The 5-Amino-1MQ research profile covers the mechanism in full.
Does the charge on 5-Amino-1MQ change with pH?
No. Methylation of the ring nitrogen quaternises it, so 5-Amino-1MQ is a permanently charged aromatic cation at any pH. It is isolated as a salt with a counter-ion, and the quoted formula refers to the cation alone.
What signal does 5-Amino-1MQ give in mass spectrometry?
In positive-mode electrospray the cation gives a single predominant ion at m/z 159. That matches the cation mass of 159.21 g/mol, which makes identity simpler to read than the multiply charged envelope seen with peptides.
How does 5-Amino-1MQ differ from SAM-analogue methyltransferase inhibitors?
5-Amino-1MQ is much smaller. The cation is under 200 Da and crosses cell membranes, while bisubstrate and SAM-analogue methyltransferase inhibitors are larger and poorly membrane permeable. It binds in the nicotinamide substrate pocket of NNMT and competes with nicotinamide.
Is 5-Amino-1MQ a peptide?
No. It is a small molecule, 5-amino-1-methylquinolinium, with no amino acids. NuVion stocks it alongside the peptide range as a research material.
What does 1MQ stand for?
1-methylquinolinium, the core ring structure of the molecule. The 5-amino part names the amine group attached to that ring.

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