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NuVion DSIP research peptide vial

DSIP

A$89.00

DSIP, delta sleep-inducing peptide, studied in NMDA receptor and adrenergic signalling research.

Research use only. Not for human or veterinary use.

In stock

All prices are in AUD. Ships from Australia with tracked express shipping, $15 flat, 1 to 2 business days, free on orders over $200. Research use only, not for human or veterinary use.

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  • Dispatched from Australia
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Research use only

Not for human or veterinary use.

Laboratory chemical

Supplied for in vitro research. We publish specifications and handling guidance only, with no protocols and no advice on use.

Not on the ARTG

Absent from the Australian Register of Therapeutic Goods and never evaluated by the TGA for safety, quality or efficacy. Absence from the register is not an approval and does not authorise any other use.

Who can order

You must be 18 or over and purchasing solely for lawful research.

What is DSIP?

DSIP, or delta sleep-inducing peptide, is a naturally occurring neuropeptide first isolated from brain tissue. It is used in neuronal culture models to study NMDA receptor and adrenergic signalling pathways, and NuVion stocks it in Australia as a 10mg lyophilised vial.

  • Naturally occurring nine amino acid neuropeptide
  • Studied in electrophysiology (EEG) research models
  • Applied in NMDA receptor and adrenergic signalling assays
  • Supplied lyophilised, purity by RP-HPLC and identity by mass spectrometry

DSIP structure and research use

DSIP is a nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It was first isolated in the 1970s and has since been detected in several tissues outside the brain. In the laboratory it is used in neuronal and neuroendocrine cell models for work on NMDA receptor and adrenergic signalling.

DSIP research applications

  • Whole-cell patch clamp measurement of NMDA receptor currents in primary neurons, run with scrambled-sequence controls
  • Calcium imaging in neuronal or neuroendocrine culture using Fura-2 or a genetically encoded indicator
  • Hormone secretion assays in pituitary cell culture, with conditioned medium quantified by ELISA or radioimmunoassay
  • Structure-activity studies comparing native DSIP, phosphorylated DSIP and scrambled-sequence analogues under identical conditions

DSIP key facts

Type Naturally occurring neuropeptide
Amino acid count 9
Sequence H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH
Molecular formula C35H48N10O15
Molecular weight 848.8 g/mol
CAS number 62568-57-4
Also known as Delta sleep-inducing peptide, DSIP
Vial size 10mg, lyophilised
Purity 99.80% by RP-HPLC, Janoshik Analytical
Analysed 24 September 2026

Research profile: DSIP: structure, mechanism and research use

Independent test: a sample of this product was analysed by Janoshik Analytical on 24 September 2026, purity 99.80% by RP-HPLC, test number 234333. The full report opens from the lab band on this page.

Why buy DSIP from NuVion

Testing status on every page

Published results show the measured purity, the date and the certificate.

Australian stock, domestic post

Held in Australia and sent tracked in plain outer packaging.

Specifications

Storing and handling DSIP

Before reconstitution
Keep the sealed vial cool, dry and out of direct light. General practice for lyophilised peptides.
After reconstitution
Reconstitute with bacteriostatic or sterile water, store at 2 to 8°C and avoid repeated freeze-thaw cycles. No stability-tested shelf life is published for this product.

Reconstitution and storage Volumes, concentrations and storage at a glance.

DSIP questions

Where can I buy DSIP in Australia?
NuVion stocks DSIP in Australia as a 10mg vial of lyophilised powder, posted from Australian stock on a tracked express service. A sample was analysed by Janoshik Analytical on 24 September 2026, with purity of 99.80% by RP-HPLC. Bacteriostatic water is sold separately. DSIP is supplied as a research material only and is not on the Australian Register of Therapeutic Goods.
What is DSIP used for in research?
It is used as a defined neuropeptide stimulus in electrophysiology and calcium imaging on neuronal preparations, in second messenger assays on adrenergic signalling, and in hormone secretion work on cultured pituitary cells. It is also a common subject for structure-activity comparison with its analogues.
How does DSIP work at the cell level?
No high-affinity receptor for DSIP has been cloned, and after five decades of work the molecular target remains undefined. The mechanistic literature is therefore built on measured cellular responses instead of on a receptor-ligand model. In neuronal culture and in synaptosomal preparations, DSIP has been reported to modulate glutamatergic signalling, with effects on NMDA receptor currents and on calcium influx measured by patch clamp and by fluorescent calcium imaging. The DSIP research profile covers the mechanism in full.
Why can DSIP be quantified at 280 nm?
The N-terminal tryptophan absorbs at 280 nm and fluoresces near 350 nm, so DSIP can be followed by UV detection during RP-HPLC and quantified by absorbance without derivatisation. The same residue is prone to oxidation and photodegradation, so solutions are kept out of the light.
Does DSIP have a defined structure in solution?
No. Three glycines and two alanines make up more than half the sequence, which leaves the backbone highly flexible. NMR and circular dichroism work describe a disordered ensemble that samples turn-like conformations transiently.
Why is negative mode preferred for DSIP mass spectrometry?
DSIP has a small mass and no basic residues, so it ionises poorly in positive mode. Aspartate at position five and glutamate at position nine give a net charge near minus two at neutral pH, and negative mode is often used for LC-MS quantification.
What does DSIP stand for?
Delta sleep-inducing peptide, the name it was given when it was first isolated in the 1970s. It is a nine amino acid peptide.

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