GHRP-6 is a synthetic hexapeptide active at the ghrelin and growth hormone secretagogue receptor family. It is used in pituitary somatotroph culture as a reference compound in secretagogue receptor research, and NuVion stocks it in Australia as a 10mg lyophilised vial.
- Synthetic hexapeptide active at the ghrelin and GHS receptor family
- Used in pituitary somatotroph culture models
- Applied in calcium flux and second messenger assays
- Supplied lyophilised, purity by RP-HPLC and identity by mass spectrometry
GHRP-6 structure and research use
GHRP-6 has the sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 and was one of the first synthetic growth hormone releasing peptides to be characterised. It is an agonist of the ghrelin receptor GHS-R1a, in the same family as GHRP-2 and ipamorelin. In the laboratory it is used as a reference compound in somatotroph culture and secretagogue receptor pharmacology.
GHRP-6 research applications
- Competition binding with radiolabelled or fluorescent ligands on GHS-R1a membranes to obtain Ki values against ghrelin
- FLIPR calcium mobilisation in GHS-R1a-expressing HEK293 or CHO lines as a fast readout of Gq coupling
- IP-One HTRF inositol phosphate assays measuring PLC-beta activation, constitutive receptor activity and inverse agonism
- RP-HPLC method development and stability studies built on tryptophan absorbance at 280 nm
GHRP-6 key facts
| Type | Synthetic peptide, growth hormone secretagogue, GHS-R1a agonist |
|---|---|
| Amino acid count | 6 residues, C-terminal amide |
| Sequence | His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 |
| Also known as | Growth hormone releasing peptide 6, GH-releasing hexapeptide, SKF-110679 |
| Vial size | 10mg, lyophilised |
| Purity | 99.61% by RP-HPLC, Janoshik Analytical |
| Analysed | 10 April 2026 |
Research profile: GHRP-6: structure, mechanism and research use
Independent test: a sample of this product was analysed by Janoshik Analytical on 10 April 2026, purity 99.61% by RP-HPLC. The certificate is shown in the lab band on this page.
