Bronchogen is a synthetic tetrapeptide bioregulator (Ala-Glu-Asp-Leu) from the Khavinson short peptide series. It is studied for interaction with DNA at CNG methylation sites and for its effect on lung-specific gene expression in cell models, and NuVion stocks it in Australia as a 20mg lyophilised vial.
- Synthetic tetrapeptide bioregulator (Ala-Glu-Asp-Leu)
- Studied for DNA interaction at CNG methylation sites
- Used in bronchial epithelial cell culture research
- Supplied lyophilised, purity by RP-HPLC and identity by mass spectrometry
Bronchogen structure and research use
Bronchogen is four amino acids long, Ala-Glu-Asp-Leu, which is where the short name AEDL comes from. It belongs to the Khavinson series of short peptide bioregulators and shares its first three residues with Epithalon (AEDG) and Cardiogen (AEDR), differing only at the fourth. In the laboratory it is used in bronchial epithelial cell culture for work on DNA binding and gene expression.
Bronchogen (AEDL) research applications
- Circular dichroism, thermal denaturation and gel-shift assays test binding to short synthetic DNA duplexes containing CNG motifs
- qPCR or RNA-seq profiles lineage and differentiation marker transcripts in bronchial epithelial and fibroblast cultures
- Immunocytochemistry and Western blot quantify differentiation marker proteins in primary and immortalised airway cell lines
- LC-MS peptidase stability assays follow loss of the parent tetrapeptide in serum and cell lysate
Bronchogen (AEDL) key facts
| Type | Synthetic tetrapeptide bioregulator |
|---|---|
| Amino acid count | 4 |
| Sequence | H-Ala-Glu-Asp-Leu-OH (AEDL) |
| Molecular formula | C19H32N4O8 |
| Molecular weight | 446.5 g/mol |
| Series | Khavinson short peptide bioregulators |
| Also known as | AEDL, Ala-Glu-Asp-Leu, bronchogen tetrapeptide |
| Vial size | 20mg, lyophilised |
| Purity | 99.77% by RP-HPLC, Janoshik Analytical |
| Analysed | 9 April 2026 |
Research profile: Bronchogen: structure, mechanism and research use
Independent test: a sample of this product was analysed by Janoshik Analytical on 9 April 2026, purity 99.77% by RP-HPLC. The certificate is shown in the lab band on this page.
