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NuVion SS-31 research peptide vial

SS-31

A$79.00

SS-31, a mitochondria-targeted peptide studied in cellular energy research.

Research use only. Not for human or veterinary use.

In stock

All prices are in AUD. Ships from Australia with tracked express shipping, $15 flat, 1 to 2 business days, free on orders over $200. Research use only, not for human or veterinary use.

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Research use only

Not for human or veterinary use.

Laboratory chemical

Supplied for in vitro research. We publish specifications and handling guidance only, with no protocols and no advice on use.

Not on the ARTG

Absent from the Australian Register of Therapeutic Goods and never evaluated by the TGA for safety, quality or efficacy. Absence from the register is not an approval and does not authorise any other use.

Who can order

You must be 18 or over and purchasing solely for lawful research.

What is SS-31?

SS-31, also known as elamipretide, is a mitochondria-targeted tetrapeptide with affinity for cardiolipin in the inner mitochondrial membrane. It is used in cardiomyocyte, renal and neuronal culture to study ATP production and reactive oxygen species, and NuVion stocks it in Australia as a 10mg lyophilised vial.

  • Mitochondria-targeted tetrapeptide with affinity for cardiolipin
  • Used in cardiomyocyte, renal and neuronal culture models
  • Applied in ATP production and reactive oxygen species assays
  • Supplied lyophilised, purity by RP-HPLC and identity by mass spectrometry

SS-31 structure and research use

SS-31 has the sequence D-Arg-Dmt-Lys-Phe-NH2, where Dmt is 2′,6′-dimethyltyrosine. Its alternating aromatic and basic residues let it cross cell membranes and concentrate at the inner mitochondrial membrane, where it associates with the phospholipid cardiolipin. In the laboratory it is used in cardiomyocyte, renal and neuronal models for work on mitochondrial membrane function, ATP production and reactive oxygen species.

SS-31 research applications

  • Extracellular flux analysis or high-resolution respirometry in cultured cells, permeabilised cells and isolated mitochondria
  • Membrane potential by TMRM or JC-1 and mitochondrial superoxide by MitoSOX in cultured cells
  • Cardiolipin-containing liposome studies by isothermal titration calorimetry, zeta potential and solid-state NMR
  • Cristae morphology by electron microscopy and respiratory supercomplex assembly by blue native PAGE

SS-31 key facts

Type Synthetic tetrapeptide, mitochondria-targeted aromatic-cationic peptide
Amino acid count 4, C-terminal amide
Sequence D-Arg-Dmt-Lys-Phe-NH2 (Dmt = 2′,6′-dimethyl-L-tyrosine)
Also known as Elamipretide, MTP-131, Bendavia, Szeto-Schiller peptide 31
Vial size 10mg, lyophilised
Purity 99.86% by RP-HPLC, Janoshik Analytical
Analysed 10 April 2026

See how SS-31 compares in MOTS-C vs SS-31. NuVion also sells SS-31 in the Cellular Ageing Set (Extended), with each compound in its own vial.

Research profile: SS-31: structure, mechanism and research use

Independent test: a sample of this product was analysed by Janoshik Analytical on 10 April 2026, purity 99.86% by RP-HPLC. The certificate is shown in the lab band on this page.

Why buy SS-31 from NuVion

Testing status on every page

Published results show the measured purity, the date and the certificate.

Australian stock, domestic post

Held in Australia and sent tracked in plain outer packaging.

Specifications

Chemical structure of SS-31 SS-31 certificate of analysis from Janoshik Analytical, 99.86% purity
CAS Number 736992-21-5
Molecular Weight 639.8
Molecular Formula C32H49N9O5

Storing and handling SS-31

Before reconstitution
Keep the sealed vial cool, dry and out of direct light. General practice for lyophilised peptides.
After reconstitution
Reconstitute with bacteriostatic or sterile water, store at 2 to 8°C and avoid repeated freeze-thaw cycles. No stability-tested shelf life is published for this product.

Reconstitution and storage Volumes, concentrations and storage at a glance.

SS-31 questions

Where can I buy SS-31 in Australia?
NuVion stocks SS-31 in Australia as a 10mg vial of lyophilised powder, posted from Australian stock on a tracked express service. A sample was analysed by Janoshik Analytical on 10 April 2026, with purity of 99.86% by RP-HPLC. It also comes in the Cellular Ageing Set (Extended). Bacteriostatic water is sold separately. SS-31 is supplied as a research material only and is not on the Australian Register of Therapeutic Goods.
What is SS-31 used for in research?
It is used as a cardiolipin-binding tool peptide in mitochondrial bioenergetics and in model membrane biophysics, including cytochrome c peroxidase chemistry. Typical readouts are oxygen consumption, membrane potential, mitochondrial superoxide and cristae structure in cultured cells or isolated mitochondria.
How does SS-31 work at the cell level?
SS-31 crosses the plasma membrane in a non-saturable, energy-independent manner and concentrates in mitochondria, reaching estimated inner-membrane concentrations several hundred to a thousand times those in the medium. Unlike lipophilic cations such as triphenylphosphonium conjugates, its uptake does not depend on mitochondrial membrane potential, so it accumulates in depolarised mitochondria as well as polarised ones. The SS-31 research profile covers the mechanism in full.
Why does SS-31 carry a net charge of +3?
At neutral pH the arginine guanidinium, the lysine side-chain amine and the N-terminal amine are all protonated. The C-terminus is an amide, so SS-31 has no carboxylate to offset those three positive charges.
Why does SS-31 begin with a D-amino acid?
The N-terminal D-arginine blocks aminopeptidase cleavage. The second residue, dimethyltyrosine, is a tyrosine carrying two methyl groups either side of the phenolic hydroxyl. They raise the electron density of the phenol, which acts as a radical scavenger in cell-free assays.
Which ions identify SS-31 in mass spectrometry?
In positive-mode electrospray SS-31 is expected to show a protonated molecular ion at m/z 640.4 and a doubly charged ion at m/z 320.7. The molecular mass is 639.8 g/mol, and on a C18 column the peptide elutes early because of its charge.
Is SS-31 the same as elamipretide?
Yes. Elamipretide is the generic name for SS-31. The SS stands for Szeto-Schiller, the two researchers who designed the peptide series it belongs to.

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