FOXO4-DRI is a D-retro-inverso senolytic peptide that targets the FOXO4-p53 interaction. It is studied for selectively inducing apoptosis in senescent cells while sparing healthy proliferating cells, following the de Keizer group’s 2017 work.
- D-retro-inverso senolytic peptide targeting FOXO4-p53
- Selectively induces apoptosis in senescent cells
- Spares healthy proliferating cells in culture studies
- Pioneered by de Keizer group (Cell, 2017)
- Studied in ageing and cellular senescence research
Research profile: FOXO4-DRI: structure, mechanism and research use






