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NuVion FOXO4-DRI research peptide vial

FOXO4-DRI

A$199.00

FOXO4-DRI, a senolytic peptide studied in senescent cell and cellular ageing research.

Research use only. Not for human or veterinary use.

In stock

All prices are in AUD. Ships from Australia with tracked express shipping, $15 flat, 1 to 2 business days, free on orders over $200. Research use only, not for human or veterinary use.

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Research use only

Not for human or veterinary use.

Laboratory chemical

Supplied for in vitro research. We publish specifications and handling guidance only, with no protocols and no advice on use.

Not on the ARTG

Absent from the Australian Register of Therapeutic Goods and never evaluated by the TGA for safety, quality or efficacy. Absence from the register is not an approval and does not authorise any other use.

Who can order

You must be 18 or over and purchasing solely for lawful research.

What is FOXO4-DRI?

FOXO4-DRI is a D-retro-inverso senolytic peptide that targets the FOXO4-p53 interaction. It is studied for selectively inducing apoptosis in senescent cells while sparing healthy proliferating cells, following the de Keizer group’s 2017 work, and NuVion stocks it in Australia as a 10mg lyophilised vial.

  • D-retro-inverso senolytic peptide targeting FOXO4-p53
  • Studied for selective apoptosis in senescent cell models
  • Pioneered by the de Keizer group (Cell, 2017)
  • Supplied lyophilised, purity by RP-HPLC and identity by mass spectrometry

FOXO4-DRI structure and research use

FOXO4-DRI is modelled on the part of the FOXO4 protein that binds p53. It is made from D-amino acids in reversed order, the D-retro-inverso design that the DRI in its name refers to, which makes a peptide resistant to breakdown by proteases. It was described by the de Keizer group in Cell in 2017. In the laboratory it is used in senescent cell culture, compared against proliferating cells, for work on the FOXO4-p53 interaction.

FOXO4-DRI research applications

  • Annexin V flow cytometry and caspase 3 and 7 activity assays compare paired senescent and proliferating cultures
  • Senescence-associated beta-galactosidase staining quantifies senescent cell burden in culture before and after peptide exposure
  • Immunofluorescence co-localisation of FOXO4 and p53 in nuclear foci tests disruption of the protein complex directly
  • Multiplex immunoassay on conditioned medium profiles interleukin and matrix metalloproteinase output of the secretory phenotype

FOXO4-DRI key facts

Type Synthetic D-retro-inverso peptide
Amino acid count Approximately 45 residues
Design D-amino acids in reversed sequence order
Parent protein FOXO4 forkhead transcription factor
Molecular target FOXO4 to p53 protein interaction
Cell-penetrating element N-terminal transduction sequence
Also known as FOXO4 DRI, FOXO4-D-retro-inverso peptide, Proxofim
Vial size 10mg, lyophilised
Purity 99.79% by RP-HPLC, Janoshik Analytical
Analysed 30 January 2026

Research profile: FOXO4-DRI: structure, mechanism and research use

Independent test: a sample of this product was analysed by Janoshik Analytical on 30 January 2026, purity 99.79% by RP-HPLC. The certificate is shown in the lab band on this page.

Why buy FOXO4-DRI from NuVion

Testing status on every page

Published results show the measured purity, the date and the certificate.

Australian stock, domestic post

Held in Australia and sent tracked in plain outer packaging.

Specifications

Chemical structure of FOXO4-DRI Janoshik test report, FOXO4-DRI, purity 99.785%
CAS Number 2460055-10-9
Molecular Weight 5358
Molecular Formula C228H388N86O64

Storing and handling FOXO4-DRI

Before reconstitution
Keep the sealed vial cool, dry and out of direct light. General practice for lyophilised peptides.
After reconstitution
Reconstitute with bacteriostatic or sterile water, store at 2 to 8°C and avoid repeated freeze-thaw cycles. No stability-tested shelf life is published for this product.

Reconstitution and storage Volumes, concentrations and storage at a glance.

FOXO4-DRI questions

Where can I buy FOXO4-DRI in Australia?
NuVion stocks FOXO4-DRI in Australia as a 10mg vial of lyophilised powder, posted from Australian stock on a tracked express service. A sample was analysed by Janoshik Analytical on 30 January 2026, with purity of 99.79% by RP-HPLC. Bacteriostatic water is sold separately. FOXO4-DRI is supplied as a research material only and is not on the Australian Register of Therapeutic Goods.
What is FOXO4-DRI used for in research?
It is used as a senolytic tool compound in cell culture, applied to populations in which senescence has been induced so that apoptotic response, senescence marker expression and secretory output can be compared against proliferating controls.
How does FOXO4-DRI work at the cell level?
In cells that have entered senescence, FOXO4 is reported to associate with p53 and hold it in nuclear foci. FOXO4-DRI is designed to compete with that interaction, and it is used in senescent cell culture to study what follows when the two proteins are separated. The FOXO4-DRI research profile covers the mechanism in full.
What is the transduction sequence on FOXO4-DRI?
It is an arginine-rich cell-penetrating segment at the N-terminus of FOXO4-DRI, fused to the interaction-blocking segment derived from the FOXO4 forkhead domain. It lets a peptide of this size reach the nucleus of a cultured cell without transfection reagent.
Why are low-binding tubes used with FOXO4-DRI?
FOXO4-DRI carries a strong net positive charge and binds avidly to glass and some plastics. Low-binding tubes and tips reduce adsorption losses, which matter because working concentrations are low and every transfer between tubes costs material.
How is the identity of FOXO4-DRI confirmed?
Identity is confirmed by mass and fragmentation pattern on mass spectrometry. Every residue in FOXO4-DRI is the D form, which makes the peptide resistant to standard enzymatic sequencing approaches. At around 5.2 kDa it is one of the larger research peptides.
What does DRI mean in FOXO4-DRI?
D-retro-inverso. The peptide is built from D-amino acids in the reverse order of the natural sequence, a design that resists breakdown by proteases.

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